睫状神经营养因子受体rs41274853多态性与日本举重运动员的举重性能相关,The Journal of Strength & Conditioning Research

H，Kobatake，N，Sekimoto，Y，Saito，M，Mochizuki，Y，Okamoto，T，Nakazato，K，Nishiyama，T，and Kikuchi，N.睫状神经营养因子受体rs41274853多态性与日语中的举重表现有关举重运动员。J Strength Cond Res 34（11）：3037–3041，2020年—至少有69个遗传标记与强力运动员相关状态。在本研究中，我们调查了日本举重运动员睫状神经营养因子受体（CNTFR）rs41274853多态性的基因型频率以及特定CNTFR基因型与举重性能之间的关联。165名日本举重运动员（103名男性和62名女性）和338名对照（122名男性和216名女性）参加了本病例对照研究。使用Oragene DNA自收集试剂盒收集唾液样品，并使用TaqMan分析对CNTFR（rs41274853）多态性进行基因分型。问卷调查记录了每个受试者在正式举重比赛中的最佳记录，用于获得举重成绩。CNTFR基因型CC，CT和TT的频率在举重运动员中分别为56、32、12％，在对照组中分别为53、40和7％，分别。举重运动员和对照组之间的CNTFR基因型频率没有显着差异。但是，国际水平的举重运动员的CT + TT基因型频率明显高于国家水平的举重运动员。CT + TT基因型运动员的抓举，挺举和挺举的相对体重值和总记录明显高于CC基因型运动员（（p＜0.05）。我们的结果表明，CNTFR rs41274853 CT + TT基因型与日本举重运动员的举重表现相关。CNTFR rs41274853的多态性可使教练为个别运动员制定量身定制的训练计划。此外，在评估潜在的运动天赋并为其运动员制定力量训练计划时，力量和条件教练会从遗传信息中受益。

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Ciliary Neurotrophic Factor Receptor rs41274853 Polymorphism Is Associated With Weightlifting Performance in Japanese Weightlifters

Homma, H, Kobatake, N, Sekimoto, Y, Saito, M, Mochizuki, Y, Okamoto, T, Nakazato, K, Nishiyama, T, and Kikuchi, N. Ciliary neurotrophic factor receptor rs41274853 polymorphism is associated with weightlifting performance in Japanese weightlifters. J Strength Cond Res 34(11): 3037–3041, 2020—At least 69 genetic markers are associated with power athlete status. In the present study, we investigated the genotype frequency of the ciliary neurotrophic factor receptor (CNTFR) rs41274853 polymorphism and the association between specific CNTFR genotype and weightlifting performance in Japanese weightlifters. One hundred sixty-five Japanese weightlifters (103 men and 62 women) and 338 controls (122 men and 216 women) participated in the present case-control study. Saliva samples were collected using the Oragene DNA self-collection kit and genotyping for the CNTFR (rs41274853) polymorphism was performed using the TaqMan assay. A questionnaire, noting each subject's best record in an official weightlifting competition, was used to obtain the weightlifting performance. The frequencies of the CNTFR genotypes CC, CT, and TT were 56, 32, 12% in the weightlifters, and 53, 40, and 7% in the controls, respectively. There was no significant difference in CNTFR genotype frequencies between the weightlifters and controls. However, the frequency of the CT + TT genotype was significantly higher in international-level weightlifters than in the national-level weightlifters. The relative value per body weight of snatch, clean, and jerk, and total record were significantly higher in the athletes with CT + TT genotype than in the athletes with CC genotype (p < 0.05). Our results suggest that the CNTFR rs41274853 CT + TT genotype is associated with weightlifting performance in Japanese weightlifters. The CNTFR rs41274853 polymorphism may enable coaches to develop tailor-made training programs for individual athletes. In addition, strength and conditioning coaches could benefit from genetic information when assessing potential athletic talents and creating strength training programs for their athletes.